Anyone following it has seen huge returns. This model, which simulates every game 10,000 times, enters the 2022 MLB season coming off a 209-178 record on top-rated MLB moneyline picks in 2021, returning more than $700 to $100 players. Before making any Opening Day MLB picks or parlays on those games or others, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model. Other key games include the reigning AL champion Astros (+110) taking on reigning AL MVP Shohei Ohtani and the Angels and the Cubs hosting the rival Brewers (-180). (Two other games have already been postponed because of weather concerns.) The game is one of seven scheduled for Opening Day. Atlanta is a -180 moneyline favorite in the latest MLB odds from Caesars Sportsbook, while Cincinnati is a +160 underdog. Lefty Max Fried, who went 14-7 last season, takes the mound for the Braves and will face the Reds' Tyler Mahle (13-6). The reigning World Series champion Atlanta Braves begin defense of their title on Thursday when they host the Cincinnati Reds in a 2022 MLB Opening Day game at Truist Park in Atlanta.
